Design and Directed Evolution of Artificial Metalloenzymes for Selective Catalysis

Design and Directed Evolution of Artificial Metalloenzymes for Selective Catalysis

Design and Directed Evolution of Artificial Metalloenzymes for Selective Catalysis (#253)

Jared Lewis ¹

Indiana University, Bloomington, IN, United States

Metalloenzymes perform some of the most remarkable transformations in nature under ambient conditions in complex cellular milieu. The possibility of leveraging molecular recognition and evolution for non-biological metal catalysts has driven efforts to engineer artificial metalloenzymes (ArMs), hybrid catalysts comprised of synthetic metal cofactors linked to protein scaffolds. In this talk, I will discuss recent efforts from my group to design and evolve ArMs containing dirhodium and metal polypyridine cofactors for selective catalysis.

doi: 10.1021/acs.accounts.8b0
doi: 10.1039/d1sc05792h

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Authors contributing to this presentation.

Lewis, J

Jared C. Lewis was born and raised in Effingham, IL. He obtained his B.S. in chemistry from the University of Illinois (2002, Prof. Eric Oldfield), earned his Ph.D. in chemistry from the University of California, Berkeley (2007, Profs. Jonathan Ellman and Robert Bergman), and conducted postdoctoral studies at Caltech (2010, Prof. Frances Arnold). He started his independent career at the University of Chicago in 2011, moved to Indiana University as an Associate Professor in 2018, and was promoted to Professor of Chemistry in 2023. His group engineers enzymes and develops new protein engineering tools to enable selective chemical transformations.

Design and Directed Evolution of Artificial Metalloenzymes for Selective Catalysis (#253)

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Lewis, J

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