Potent photocytotoxicity of ternary thiosemicarbazone complexes of oxovanadium(IV) and copper(II) towards cancer cells — ASN Events
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  3.   Potent photocytotoxicity of ternary thiosemicarbazone complexes of oxovanadium(IV) and copper(II) towards cancer cells

  Potent photocytotoxicity of ternary thiosemicarbazone complexes of oxovanadium(IV) and copper(II) towards cancer cells (#234)

Musa S. Shongwe 1 , Iman K. Al Salmi 1 , Craig C. Robertson 2 , Samya Banerjee 3
  1. CHEMISTRY, Sultan Qaboos University, Muscat, Oman
  2. CHEMISTRY, University of Sheffield, Sheffield, UK
  3. CHEMISTRY, Indian Institute of Technology (BHU), Varanasi, India

There is considerable interest in thiosemicarbazone ligands due to their strong affinity for a diverse range of metal ions1 and their coordination versatility deriving from their propensity to undergo base-/metal-assisted tautomerization. Moreover, their inherent multifarious pharmacological behavior is enhanced upon complexation with bioactive transition-metal ions. In this research endeavor, ternary thiosemicarbazone complexes of oxovanadium(IV) and copper(II) with the bidentate heterocyclic co-ligands 1,10-phenanthroline (phen) and 2,2´-bipyridine (bipy) (or their derivatives) were designed, synthesized and characterized by a wide range of physicochemical techniques. Crystallographically elucidated ternary thiosemicarbazate oxovanadium(IV) complexes2–4 are very rare indeed; herein we present single-crystal  X-ray structures of the corresponding oxovanadium(IV) thiosemicarbazone complexes hitherto nonexistent. These oxovanadium(IV)  complexes and their copper(II)5 counterparts have been investigated for antiproliferative activity in HeLa and MCF-7 cancer cell lines in the presence and absence of visible electromagnetic radiation. Moreover, in some cases, selectivity involving the MCF-10 normal cancer cells has been investigated with fascinating findings.

 

  1. Lobana, T. S. et al., Coord. Chem. Rev. 2009, 253, 977–1055.
  2. Koo, B. K. et al., Bull. Korean Chem. Soc. 2005, 26, 72–76.
  3. Chakravarty, A. R. et al., J. Inorg. Biochem. 2008, 102, 1463–1472.
  4. Chaudhury, M. et al., Polyhedron 1997, 16, 1863–1871.
  5. Al Salmi, I. K. & Shongwe., M. S., Molecules, 2024, 29, 431.
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