Markos Koutmos is an Associate Professor in the Departments of Chemistry and Biophysics at the University of Michigan, also affiliated with the Department of Biological Chemistry and Programs in Chemical Biology and Cancer Biology. Since joining the University of Michigan in 2018, after beginning his independent career at the Uniformed Services University of the Health Sciences, Dr. Koutmos has led a lab focused on understanding how the 3D structure and dynamics of proteins and RNAs drive their biological function. The Koutmos lab's research aims to build foundational knowledge of enzymatic chemistries, understand biomacromolecules' roles in disease, and discover new therapeutic targets, focusing on metalloenzyme structure and function, RNA modifications and processing, and RNA structure and dynamics. The lab provides molecular-level insights into enzyme catalysis, including how enzymes use cofactors and how tRNA processing enzymes contribute to tRNA biogenesis. Additionally, the Koutmos lab develops chemical tools to target RNA structures and RNA-protein interactions, modulate biological macromolecule activity, and explore novel therapeutic avenues, ultimately offering valuable insights into enzyme catalysis and tRNA biogenesis for the development of new chemical biology tools and therapeutics.